Azacitidine
Azacitidine: View Uses, Side Effects and Medicines
Introduction to Azacitidine
Azacitidine is a cancer drug with the most extensive use being in the management of certain blood disorders and cancers, i.e., myelodysplastic syndromes (MDS). Azacitidine does its work by changing the DNA of the cancer cells, thereby inhibiting their growth and production. This article discusses in a detailed manner how Azacitidine works, its applications, side effects, and measures to be adopted during the administration of the anti-cancer drug.
Uses of Azacitidine
Azacitidine is generally used to manage:
- Myelodysplastic syndromes (MDS)
- Acute myeloid leukemia (AML)
- Chronic myelomonocytic leukemia (CMML)
Other Cancers of The Blood
Those who are not suitable candidates for undergoing stem cell transplantation receive this cancer drug. Azacitidine is used to increase the number of blood cells, thereby minimizing blood transfusions. The effectiveness of how Azacitidine works has rendered it a key component of cancer treatment protocols globally.
How Azacitidine Works
Azacitidine belongs to a class of drugs that is categorized as hypomethylating drugs and act by getting inside the DNA and RNA of the cancer cells. Azacitidine acts by stopping DNA methylation, thereby preventing the abnormal cells from growing. Azacitidine also induces the re-activation of anticancer genes during the process, with the final result being the death of the cancer cells.
Apart from that, this cancer medication also promotes the natural process of bone marrow, where today it is possible to build healthier blood cells. By its action, how Azacitidine works has been a patient's fantasy for a long in patients with hematologic cancers.
AVAILABLE MEDICINE FOR AZACITIDINE
Azadine 100mg Injection
Azadine O 300mg Tablet
Azatend O 300mg Tablet
Azishil 100mg Injection
Hemazide O 200mg Tablet
Hemazide O 300mg Tablet
Common Side Effects of Azacitidine
Even though Azacitidine is a good cancer medication, it also has side effects. Some of the common side effects of Azacitidine are:
- Nausea and vomiting
- Fatigue
- Fever
- Diarrhea or constipation
- Loss of appetite
- Reaction at the site of injection (pain, redness, swelling)
- Low blood levels (anaemia, neutropenia, thrombocytopenia)
One must visit a physician if the above common side effects of Azacitidine continue or continue to worsen over time. One may experience side effects other than the aforementioned that are experienced by the patients such as shortness of breath, chest pain, or skin reaction, and in the meantime, one should seek immediate medical attention.
Precautions Before Using Azacitidine
Precautions before treatment with Azacitidine are required for patient safety. Some precautions to be taken are:
- Pregnancy and Lactation: Pregnancy or lactation should be avoided during the administration of this anticancer drug. Child-bearing female patients should use effective contraception.
- Kidney and Liver Function: Azacitidine can be given in patients with pre-existing kidney or liver disease only after medical evaluation.
- Risk of Infection: Because this anti-cancer medication decreases blood cell counts, there is more risk of infection. Social interaction should be avoided by patients, and they need to be neat.
- Tendency to Bleed: As it decreases the count of platelets, nothing that can harm or cause bleeding is allowed to be done to patients.
- Allergic Reactions: If the patient has already developed allergic reactions against Azacitidine or other similar medicines, alternative medication or treatment is sought.
Following these precautions, there are no side effects, and treatment with Azacitidine is sought in the best possible manner.
Drugs With Azacitidine
Azacitidine is marketed under a variety of different brand names as an anti-cancer medication. Some of the most commonly used drugs are:
- Vidaza
- Azadine
- Onureg
- Azacitidine Injection (Generic)
Physicians prescribe the right drug based on the patient's condition along with the patient's capability to undergo the therapy. Anti-cancer drugs come in tablet and injectable forms of different capacities based on the intensity of the disease.
Side Effects of Azacitidine Management
To manage Azacitidine's most frequent side effects, patients can:
- Drink a lot of water to avoid diarrhoea and dehydration from vomiting.
- Follow a good diet to build strength and prevent fatigue.
- Report to the doctor any bruising or bleeding that is not explained.
- Use anti-nausea medications as directed by the doctor.
- Prevent the risk of infection with good hygiene.
Although side effects from standard Azacitidine are unpleasant, they are generally managed by supportive care and medical intervention.
Azacitidine has transformed the treatment of myelodysplastic syndromes and some leukaemias. Knowing how Azacitidine works, Azacitidine side effects and precautions can be of immense assistance in maximizing the outcome of the treatment. It is an excellent anti-cancer drug and hope for all cancer patients with blood cancer. Always consult a doctor before taking Azacitidine to obtain safe and effective treatment.
With their full knowledge about this anti-cancer drug, patients and caregivers can make the right decisions in their treatment process and detect any issues correctly.
FAQ
Azacitidine is used to treat myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML). Azacitidine increases blood cell production and prevents the growth of cancer cells.
How Azacitidine accomplishes this by inhibiting DNA methylation in cancer cells, which activates tumour-suppressing genes and spurs normal blood cell development.
The most common side effects of Azacitidine are nausea, vomiting, fatigue, diarrhoea, fever, and decreased blood counts.
Some of the precautions that may be employed here are prevention of infection, determination of allergic reaction, and determination of liver and kidney function before initiation of the therapy.
Yes, Azacitidine is an anti-cancer drug, which is greatly used to treat different kinds of cancers related to blood.
No, Azacitidine should not be consumed if one is pregnant. No, Azacitidine during pregnancy and lactation is not safe. Contraception needs to be used while taking this anti-cancer drug.
Azacitidine is administered through injection and tablet form. Dosage and treatment may differ with the patient's condition and physician's prescription.