Apotinib 400mg Tablet

Product Introduction

Apotinib 400mg Tablet is an advanced pharmaceutical formulation used in the treatment of various cancers, primarily focusing on gastrointestinal stromal tumors (GIST) and certain types of advanced non-small cell lung cancer (NSCLC). The active ingredient in Apotinib is a potent tyrosine kinase inhibitor (TKI) that specifically targets and inhibits the activity of vascular endothelial growth factor receptors (VEGFRs). This inhibition is crucial as it prevents the formation of new blood vessels that tumors require for growth and metastasis. By cutting off the blood supply, Apotinib effectively starves the tumor cells, limiting their ability to proliferate and spread.

Developed through extensive research and clinical trials, Apotinib has shown significant efficacy in patients who have not responded to standard therapies or who have developed resistance to other treatments. The medication comes in the form of a 400mg tablet, ensuring a high dosage to maximize its therapeutic impact.

Uses of Apotinib 400mg Tablet

Apotinib 400mg Tablet is primarily indicated for the following conditions:

• Gastrointestinal Stromal Tumors (GIST): Apotinib is used in the treatment of GIST, particularly in cases where tumors are unresectable or metastatic, and where other treatments have failed. Its targeted mechanism helps in managing the disease by inhibiting the growth and spread of the tumor cells.
• Advanced Non-Small Cell Lung Cancer (NSCLC): For patients with advanced NSCLC, especially those with specific genetic mutations or who have not responded to other lines of therapy, Apotinib offers a viable treatment option by targeting and inhibiting the growth factors that contribute to cancer progression.

Benefits of Apotinib 400mg Tablet

The benefits of Apotinib 400mg Tablet are substantial, particularly for patients with difficult-to-treat cancers:

1. Targeted Therapy: Apotinib’s action on VEGFRs makes it highly specific in targeting tumor cells without affecting normal cells, which reduces collateral damage and enhances the precision of cancer treatment.
2. Efficacy in Resistant Cases: It has proven effective in patients who have developed resistance to other treatments, providing a crucial alternative for continuing cancer management.
3. Reduction in Tumor Growth: By inhibiting angiogenesis, Apotinib significantly reduces the ability of tumors to grow and metastasize, which can lead to improved survival rates and quality of life for patients.
4. Oral Administration: The tablet form of Apotinib makes it convenient for patients to take at home, reducing the need for hospital visits and intravenous treatments.

Side Effects of Apotinib 400mg Tablet

While Apotinib 400mg Tablet offers significant benefits, it is also associated with a range of potential side effects. Patients and healthcare providers should be aware of these to manage them effectively:

1. Common Side Effects:
   • Hypertension (High Blood Pressure): One of the most frequently observed side effects is an increase in blood pressure, which requires regular monitoring and management.
   • Hand-Foot Syndrome: This condition is characterized by redness, swelling, and pain on the palms of the hands and soles of the feet. It can be managed with dose adjustments and symptomatic treatments.
   • Fatigue: Many patients experience significant fatigue, which can impact daily activities and quality of life.
   • Diarrhea: Gastrointestinal disturbances, including diarrhea, are common, necessitating supportive care and hydration.
2. Less Common but Serious Side Effects:
   • Cardiovascular Events: There is a risk of serious cardiovascular side effects, including heart failure and myocardial infarction, particularly in patients with preexisting heart conditions.
   • Bleeding: Apotinib can increase the risk of bleeding, especially in patients taking anticoagulants or those with a history of bleeding disorders.
   • Proteinuria: The presence of excess protein in urine, indicating potential kidney damage, requires regular renal function monitoring.
   • Thyroid Dysfunction: Changes in thyroid function, including hypothyroidism, can occur and should be regularly checked through blood tests.
3. Management of Side Effects:
   • Regular Monitoring: Frequent monitoring of blood pressure, kidney function, and thyroid levels is essential for patients on Apotinib.
   • Dose Adjustments: Depending on the severity of side effects, healthcare providers may adjust the dosage to minimize adverse reactions while maintaining therapeutic efficacy.
   • Supportive Care: Symptomatic treatments for side effects like hand-foot syndrome and diarrhea, along with lifestyle modifications and supportive care, can help manage and alleviate discomfort.

References