Product Introduction
Bevacirel 100mg Injection is a potent therapeutic formulation that has become essential in the treatment of various advanced-stage cancers. The active ingredient in Bevacirel is bevacizumab, a monoclonal antibody designed to interfere with the angiogenesis process that tumors use to grow and spread. Bevacizumab targets and inhibits the vascular endothelial growth factor (VEGF), a protein that promotes the growth of new blood vessels. By blocking VEGF, Bevacirel effectively restricts the blood supply to tumors, limiting their growth and reducing their ability to metastasize.
This medication is commonly administered under the care of a healthcare professional in a hospital or clinical setting due to its potent nature and the necessity for precise dosage and monitoring. Bevacirel 100mg is presented in a liquid form for intravenous infusion, typically over a period of 90 minutes, though subsequent infusions might be faster if well-tolerated.
Uses of Bevacirel 100mg Injection
Bevacirel 100mg Injection is primarily used to treat several types of cancers, including:
- Colorectal cancer, particularly in advanced stages, as part of combination chemotherapy.
- Non-small cell lung cancer, enhancing the effects of chemotherapy in advanced stages.
- Glioblastoma, a type of brain cancer, where it is used in cases of disease progression following initial therapy.
- Renal cell carcinoma, aiding in the treatment of advanced kidney cancer.
- Ovarian, fallopian tube, or primary peritoneal cancer in advanced stages.
The use of Bevacirel has been validated in clinical trials that show a significant improvement in survival rates and disease progression times. It is important to note that Bevacirel is usually part of a broader therapeutic regimen and is often combined with other forms of chemotherapy to maximize its efficacy.
Benefits of Bevacirel 100mg Injection
The primary benefit of Bevacirel 100mg Injection lies in its ability to inhibit the growth and spread of cancerous cells. In clinical settings, Bevacirel has shown to:
- Improve overall survival rates in patients suffering from certain types of metastatic cancers.
- Extend progression-free survival, the length of time during and after medication that a patient lives with the disease without it getting worse.
- Enhance the effectiveness of chemotherapy, leading to better treatment outcomes.
Additionally, Bevacirel has been a part of targeted therapy, offering a treatment that is specifically directed at the biological pathways of cancer progression, which often results in fewer side effects compared to traditional chemotherapy methods.
Side Effects of Bevacirel 100mg Injection
Despite its benefits, Bevacirel 100mg Injection can cause a range of side effects, which can vary in severity. The most common side effects include but are not limited to:
- Hypertension (high blood pressure)
- Fatigue
- Diarrhea
- Decreased white blood cell count, which can increase infection risk
- Nosebleeds
- Headaches
- Mouth sores
More serious side effects might include gastrointestinal perforations, wound healing complications, hemorrhage, and in rare instances, congestive heart failure or thromboembolic events. Due to these potential risks, patients undergoing treatment with Bevacirel are closely monitored by their healthcare providers.
References
1. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf
2. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson’s Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
3. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
5. Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022], https://www.gene.com/download/pdf/avastin_prescribing.pdf
6. Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]https://www.avastin.com/patient/mcrc.html
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