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Bortenat 2mg Injection
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Bortecad 2.5 Injection

Original price was: ₹3,180.00.Current price is: ₹1,900.00.

Prescription Required

Salt : Bortezomib (2.5mg)

Manufacturer : Cadila Pharmaceuticals Ltd

Packing : 1.0 Injection in 1 vial

Description

Product Introduction

Bortecad 2.5 Injection, a novel therapeutic agent, belongs to the class of medications known as proteasome inhibitors. It is formulated to combat certain types of cancers, particularly multiple myeloma—a malignancy affecting plasma cells in the bone marrow. The active ingredient, bortezomib, inhibits the proteasome—a cellular complex crucial for the breakdown of proteins involved in cell cycle regulation and apoptosis (programmed cell death). By disrupting these processes, Bortecad 2.5 Injection impedes cancer cell growth and induces cell death, thus offering a promising avenue for cancer treatment.

Uses of Bortecad 2.5 Injection

Bortecad 2.5 Injection finds primary application in the management of multiple myeloma, a hematologic malignancy characterized by the abnormal proliferation of plasma cells within the bone marrow. Additionally, it is employed in the treatment of mantle cell lymphoma, a rare and aggressive form of non-Hodgkin’s lymphoma. Its mechanism of action makes it particularly effective against these cancers by targeting specific molecular pathways involved in their progression.

Benefits of Bortecad 2.5 Injection

The utilization of Bortecad 2.5 Injection offers several notable benefits in the treatment of multiple myeloma and mantle cell lymphoma:

a. Effective Tumor Suppression: By inhibiting the proteasome, Bortecad 2.5 Injection impedes the proliferation of cancerous cells and promotes their apoptosis, thereby suppressing tumor growth.

b. Enhanced Survival Rates: Clinical studies have demonstrated that incorporating Bortecad 2.5 Injection into treatment regimens has significantly improved overall survival rates and prolonged progression-free survival in patients with multiple myeloma and mantle cell lymphoma.

c. Synergistic Effects: Bortecad 2.5 Injection can be used in combination with other chemotherapeutic agents, such as dexamethasone or immunomodulatory drugs, to potentiate their anti-cancer effects, offering a comprehensive approach to disease management.

d. Manageable Administration: As an injectable formulation, Bortecad 2.5 Injection allows for precise dosing and convenient administration, facilitating patient compliance and ensuring optimal therapeutic outcomes.

Side Effects of Bortecad 2.5 Injection

While Bortecad 2.5 Injection is generally well-tolerated, it may elicit certain adverse effects, including but not limited to:

a. Hematologic Toxicities: Bortecad 2.5 Injection can cause reversible suppression of bone marrow function, leading to decreased levels of red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia), which may manifest as fatigue, susceptibility to infections, and increased bleeding tendency.

b. Gastrointestinal Disturbances: Patients may experience nausea, vomiting, diarrhea, or constipation following administration of Bortecad 2.5 Injection, although these symptoms are typically mild to moderate in severity and can be managed with supportive care measures.

c. Peripheral Neuropathy: Sensory and motor neuropathies, characterized by tingling sensations, numbness, or weakness in the extremities, may occur as a result of Bortecad 2.5 Injection therapy. Close monitoring and dose adjustments may be warranted to mitigate this adverse effect.

d. Fatigue and Asthenia: Some individuals may experience fatigue, weakness, or generalized malaise during Bortecad 2.5 Injection treatment, which can impact daily functioning and quality of life.

e. Hypersensitivity Reactions: Rarely, allergic reactions such as rash, itching, or anaphylaxis may occur following administration of Bortecad 2.5 Injection, necessitating immediate medical attention and discontinuation of the medication.

It is imperative for healthcare providers to thoroughly educate patients about the potential side effects of Bortecad 2.5 Injection and implement appropriate monitoring strategies to promptly identify and manage any adverse reactions that may arise during the course of therapy.

In summary, Bortecad 2.5 Injection represents a significant advancement in the treatment of multiple myeloma and mantle cell lymphoma, offering efficacious tumor suppression and enhanced survival outcomes. While associated with manageable side effects, its benefits outweigh the risks, positioning it as a cornerstone of modern oncology regimens.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1742-43.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 958.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 153-54.
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link
  5. Bortezomib. Beerse Belgium: Janssen Pharmaceutica NV; [Accessed 26 Mar. 2019] (online) Available from:External Link

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