

Evergraf 0.25mg Tablet
₹700.59 Original price was: ₹700.59.₹560.47Current price is: ₹560.47.
Prescription Required
Salt : Everolimus
Manufacturer : Mankind Pharmaceuticals Limited
Packing : 10 Tablet In A Strip
PRODUCT INTRODUCTION
Evergraf 0.25mg Tablet, a potent immunosuppressive medication, is a crucial component in the treatment and management of various autoimmune disorders and organ transplant rejection. Its active ingredient, Everolimus, belongs to the class of drugs known as mammalian target of rapamycin (mTOR) inhibitors. These drugs work by inhibiting the mTOR pathway, which plays a vital role in cell growth, proliferation, and survival.
Evergraf 0.25mg Tablet is manufactured under stringent quality standards and is available in oral tablet form for convenient administration. Each tablet contains 0.25mg of Everolimus, ensuring precise dosage control. This medication is typically prescribed by healthcare professionals after thorough evaluation of the patient’s medical history, current health status, and specific condition being treated.
USES OF Evergraf 0.25mg Tablet
Organ Transplantation: Evergraf 0.25mg Tablet is widely utilized in organ transplantation to prevent organ rejection. Following a transplant procedure, the body’s immune system may recognize the new organ as foreign and mount an immune response against it. Evergraf helps suppress this response, reducing the risk of rejection and increasing the likelihood of transplant success.
Autoimmune Disorders: Evergraf 0.25mg Tablet is also employed in the management of autoimmune disorders such as rheumatoid arthritis and lupus nephritis. In these conditions, the immune system mistakenly attacks healthy tissues, leading to inflammation and tissue damage. By modulating the immune response, Evergraf helps alleviate symptoms and slows disease progression, improving the patient’s quality of life.
BENEFITS OF Evergraf 0.25mg Tablet
Effective Immunosuppression: Evergraf 0.25mg Tablet exerts potent immunosuppressive effects by inhibiting the mTOR pathway. This property is particularly beneficial in preventing organ rejection following transplantation, as well as in managing autoimmune disorders where immune overactivity contributes to tissue damage.
Reduced Rejection Risk: By suppressing the immune response, Evergraf significantly reduces the risk of transplant rejection. This allows recipients to better tolerate the transplanted organ and minimizes the need for additional interventions to address rejection episodes.
Improved Disease Control: In autoimmune disorders, Evergraf helps control disease activity by dampening the abnormal immune response. This can lead to reduced inflammation, alleviation of symptoms such as pain and swelling, and preservation of organ function over time.
Flexible Dosage Options: Evergraf 0.25mg Tablet offers flexible dosing regimens, allowing healthcare providers to tailor treatment plans to individual patient needs. This flexibility ensures optimal therapeutic outcomes while minimizing the risk of adverse effects.
SIDE EFFECTS OF Evergraf 0.25mg Tablet
While Evergraf 0.25mg Tablet offers significant therapeutic benefits, it may also be associated with certain side effects, which can vary in severity and frequency among patients. Common side effects may include:
1. Immunosuppression-Related Complications: As Evergraf suppresses the immune system, patients may be at increased risk of infections, including bacterial, viral, and fungal infections. It is essential for patients to practice good hygiene and adhere to recommended vaccination schedules to reduce this risk.
2. Metabolic Disturbances: Evergraf may affect metabolic processes, leading to complications such as hyperglycemia (high blood sugar levels), hyperlipidemia (elevated lipid levels), and electrolyte imbalances. Regular monitoring of blood glucose, lipid levels, and electrolyte levels is necessary to detect and manage these potential complications.
3. Gastrointestinal Symptoms: Some patients may experience gastrointestinal side effects such as nausea, vomiting, diarrhea, or abdominal discomfort. These symptoms are usually mild to moderate in severity and often resolve with continued treatment or dose adjustments.
4. Dermatological Reactions: Evergraf can cause dermatological side effects, including rash, acne, and pruritus (itching). These reactions are typically mild and transient but may require symptomatic treatment or dose modification in some cases.
5. Renal Dysfunction: In some patients, Evergraf may impair renal function, leading to decreased kidney function or increased risk of kidney injury. Regular monitoring of renal function parameters such as serum creatinine and urine output is essential to detect and manage renal complications promptly.
6. Other Adverse Effects: Additional side effects associated with Evergraf may include peripheral edema (fluid retention), headache, fatigue, and musculoskeletal symptoms such as arthralgia (joint pain) or myalgia (muscle pain).
References
- Novartis Pharmaceuticals UK Limited, Electronic medicines compendium (EMC), [ Revised on June 2022] [ Accessed on 18th March 2023], https://www.medicines.org.uk/emc/files/pil.6658.pdf
- Jan Hasskarl; Everolimus; Recent Results in Cancer Research; Published on 2018; Accessed on 18/03/2023;Â https://pubmed.ncbi.nlm.nih.gov/30069763/
- Novartis Pharmaceuticals Corporation, US Food and Drug Administration, [ Revised on July 2012] [ Accessed on 18th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022334s016lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Targeted therapy: tyrosine kinase inhibitors, monoclonal antibodies, and cytokines, 12th edition, 2011, 1743.
- KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 878 – 882.
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