Glador M2 Tablet PR

Product Introduction

Glador M2 Tablet PR is a prescription medication designed for the management of type 2 diabetes mellitus. This extended-release tablet is a combination of two active ingredients: Glimepiride and Metformin. Glimepiride belongs to the class of medications known as sulfonylureas, which work by stimulating the pancreas to release insulin. Metformin, on the other hand, is a biguanide that works primarily by reducing the amount of glucose produced by the liver and improving the body’s sensitivity to insulin. Together, these components help in controlling blood sugar levels effectively throughout the day.

Uses of Glador M2 Tablet PR

Glador M2 Tablet PR is primarily used to improve blood sugar control in adults with type 2 diabetes mellitus. It is often prescribed when diet and exercise alone are insufficient to control blood glucose levels. The combination of Glimepiride and Metformin provides a synergistic effect, making it more effective than either component alone. This medication helps to lower the risk of complications associated with diabetes, such as heart disease, kidney damage, blindness, and nerve problems, by maintaining blood glucose levels within the target range.

Benefits of Glador M2 Tablet PR

1. Effective Blood Sugar Control: The dual action of Glimepiride and Metformin helps in achieving better glycemic control compared to monotherapy. This combination helps to lower fasting and postprandial blood glucose levels effectively.
2. Reduced Risk of Hypoglycemia: Glimepiride stimulates insulin release in a glucose-dependent manner, reducing the risk of hypoglycemia compared to older sulfonylureas. Metformin, being an insulin sensitizer, does not cause hypoglycemia by itself.
3. Convenient Dosage: The prolonged-release (PR) formulation ensures a steady release of medication over an extended period, providing consistent blood sugar control and improving patient compliance.
4. Cardiovascular Benefits: Metformin has been shown to provide cardiovascular benefits in diabetic patients, potentially reducing the risk of heart disease and stroke.
5. Weight Neutral: Unlike some diabetes medications that can cause weight gain, Metformin is weight neutral or may even promote slight weight loss, making it suitable for overweight or obese patients with type 2 diabetes.

Side Effects of Glador M2 Tablet PR

While Glador M2 Tablet PR is generally well-tolerated, it may cause some side effects. Patients should be aware of the potential adverse reactions and consult their healthcare provider if they experience any severe or persistent symptoms.

1. Gastrointestinal Issues: The most common side effects of Metformin are gastrointestinal in nature, including nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These symptoms are usually transient and may subside with continued use.
2. Hypoglycemia: Although Glador M2 Tablet PR is designed to minimize the risk, hypoglycemia (low blood sugar) can still occur, especially if meals are skipped or if the patient engages in intense physical activity without adequate carbohydrate intake. Symptoms of hypoglycemia include dizziness, sweating, shaking, and confusion.
3. Allergic Reactions: Some patients may experience allergic reactions such as rash, itching, or swelling. Severe allergic reactions are rare but require immediate medical attention.
4. Lactic Acidosis: Although rare, Metformin can cause a serious condition called lactic acidosis, characterized by muscle pain, weakness, trouble breathing, and unusual sleepiness. This condition requires immediate medical intervention.
5. Hematologic Effects: Glimepiride can occasionally cause blood-related issues such as thrombocytopenia (low platelet count) or leukopenia (low white blood cell count). Regular blood tests may be recommended to monitor blood cell counts.
6. Vitamin B12 Deficiency: Long-term use of Metformin has been associated with decreased absorption of vitamin B12, which may lead to deficiency over time. Patients may require periodic monitoring of B12 levels and supplementation if necessary.
7. Liver and Kidney Function: Both Glimepiride and Metformin are metabolized by the liver and excreted by the kidneys. Patients with preexisting liver or kidney conditions should use Glador M2 Tablet PR with caution and under close medical supervision.