Istamet 50mg/1000mg Tablet

Product Introduction

Istamet 50mg/1000mg Tablet is a combination medication primarily used in the management of type 2 diabetes mellitus. It combines two active ingredients: Sitagliptin and Metformin. Sitagliptin is a DPP-4 (dipeptidyl peptidase-4) inhibitor, while Metformin is a biguanide. Together, these components work synergistically to improve blood glucose control in patients with type 2 diabetes.

Sitagliptin works by increasing the levels of incretin hormones, which help regulate blood sugar by stimulating insulin release and reducing glucagon levels. Metformin enhances insulin sensitivity and decreases glucose production in the liver. This combination helps in controlling blood glucose levels effectively.

Istamet 50mg/1000mg Tablet is available in a fixed-dose form, typically prescribed as part of a comprehensive diabetes management plan, including diet and exercise.

Uses of Istamet 50mg/1000mg Tablet

Istamet is used to manage and control blood glucose levels in adults with type 2 diabetes. It is not used for the treatment of type 1 diabetes or diabetic ketoacidosis. The primary uses include:

• Blood Glucose Control: Helps in maintaining blood glucose levels within the target range, thereby reducing the risk of complications associated with uncontrolled diabetes.
• Enhanced Glycemic Control: Useful in patients who have not achieved adequate glycemic control with Metformin alone or Sitagliptin alone.
• Combination Therapy: Often used when monotherapy with Metformin or Sitagliptin does not sufficiently control blood sugar levels.

Istamet is typically prescribed when diet and exercise alone, or when other oral diabetes medications, are insufficient to manage blood glucose levels.

Benefits of Istamet 50mg/1000mg Tablet

• Effective Glycemic Control: By combining two effective agents, Istamet offers better control of blood glucose levels than either drug alone.
• Reduced Risk of Hypoglycemia: Compared to some other diabetes medications, Istamet has a lower risk of causing low blood sugar (hypoglycemia) when used correctly.
• Convenient Dosing: The fixed-dose combination simplifies the treatment regimen, reducing the need for multiple medications and improving patient adherence.
• Dual Mechanism of Action: Sitagliptin helps in enhancing insulin secretion and reducing glucagon levels, while Metformin decreases glucose production in the liver and improves insulin sensitivity.
• Potential Weight Neutrality: Unlike some other diabetes medications, Istamet does not typically cause weight gain, and Metformin may even promote weight loss.

Side Effects of Istamet 50mg/1000mg Tablet

Like any medication, Istamet 50mg/1000mg Tablet may cause side effects. Common side effects include:

• Gastrointestinal Issues: These can include nausea, vomiting, diarrhea, abdominal pain, and a metallic taste in the mouth. These effects are often transient and may improve with continued use.
• Headache: Some patients may experience headaches, which can be managed with over-the-counter pain relievers if necessary.
• Skin Reactions: Rarely, patients might experience rash or itching.
• Increased Risk of Lactic Acidosis: Metformin has been associated with a rare but serious condition known as lactic acidosis, which is characterized by an accumulation of lactic acid in the blood. This is more likely to occur in patients with compromised renal function or other predisposing conditions.

Serious side effects are less common but require immediate medical attention:

• Hypoglycemia: Although rare, especially when Istamet is used alone, hypoglycemia can occur, particularly if used in conjunction with other blood sugar-lowering medications.
• Pancreatitis: There have been reports of pancreatitis (inflammation of the pancreas) associated with Sitagliptin use. Symptoms may include severe abdominal pain, nausea, and vomiting.
• Allergic Reactions: Rare but serious allergic reactions may include swelling of the face, lips, tongue, or throat, which could lead to difficulty breathing.

FAQ

Q: How should Istamet be taken? A: Istamet should be taken exactly as prescribed by your healthcare provider. It is typically taken orally, with or without food. The dosage is usually divided into two or three doses per day. Swallow the tablet whole with a glass of water; do not chew or crush it.

Q: What should I do if I miss a dose? A: If you miss a dose of Istamet, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose—do not double up to make up for a missed dose. Continue with your regular dosing schedule.

Q: Can Istamet be used in combination with other diabetes medications? A: Yes, Istamet may be used in combination with other diabetes medications if prescribed by your healthcare provider. It is important to follow your provider’s instructions and regularly monitor your blood glucose levels.

Q: Are there any dietary restrictions while taking Istamet? A: There are no specific dietary restrictions with Istamet, but maintaining a balanced diet and monitoring carbohydrate intake is important for effective diabetes management. Follow your healthcare provider’s recommendations for diet and lifestyle.

Q: What should I do if I experience severe side effects? A: If you experience severe side effects such as symptoms of lactic acidosis (muscle pain, breathing difficulties, or unusual fatigue), signs of pancreatitis (severe abdominal pain), or any serious allergic reactions, seek medical attention immediately.

Q: Can Istamet be used during pregnancy or breastfeeding? A: The safety of Istamet during pregnancy or breastfeeding has not been well-established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Disclaimer

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