Letroz 2.5mg Tablet 30’s

PRODUCT INTRODUCTION

Letroz 2.5mg Tablet 30’s is a pharmaceutical medication primarily prescribed for the treatment of specific types of breast cancer in postmenopausal women. The active ingredient in this medication is letrozole, which belongs to a class of drugs known as aromatase inhibitors. These inhibitors play a crucial role in reducing the production of estrogen in the body, which is essential because certain breast cancers grow and proliferate in response to estrogen.

Letrozole works by inhibiting the enzyme aromatase, responsible for converting androgens into estrogen. By lowering estrogen levels, Letroz 2.5mg Tablet helps to slow or even halt the growth of estrogen-dependent breast cancer cells. This medication is often utilized as part of a comprehensive treatment plan, which may include surgery, radiation, and other chemotherapy drugs.

USES OF LETROZ 2.5MG TABLET 30’S

Letroz 2.5mg Tablet is primarily used for:

1. Hormone Receptor-Positive Breast Cancer: It is effective in treating hormone receptor-positive breast cancer, which relies on estrogen to grow. By lowering estrogen levels, letrozole reduces the stimulus for cancer cell growth.
2. Early Breast Cancer: Post-surgery, Letroz 2.5mg Tablet is often prescribed to prevent the recurrence of early-stage breast cancer.
3. Advanced Breast Cancer: For patients with advanced breast cancer, letrozole can help to manage the disease and improve survival rates by slowing the progression of cancer.
4. Fertility Treatment: Though primarily a cancer medication, letrozole is sometimes used off-label to induce ovulation in women with fertility issues, particularly those with polycystic ovary syndrome (PCOS).

BENEFITS OF LETROZ 2.5MG TABLET 30’S

The benefits of Letroz 2.5mg Tablet are multifaceted, contributing significantly to both cancer treatment and overall patient quality of life:

1. Reduction in Recurrence Risk: By lowering estrogen levels, Letroz 2.5mg Tablet significantly reduces the risk of breast cancer recurrence in postmenopausal women, offering long-term protection against the disease.
2. Management of Advanced Cancer: For patients with metastatic breast cancer, letrozole provides an effective treatment option that can slow disease progression, helping to manage symptoms and improve life expectancy.
3. Enhanced Survival Rates: Clinical studies have demonstrated that letrozole can improve survival rates in women with breast cancer, making it a vital component of breast cancer therapy.
4. Non-Invasive: As an oral medication, Letroz 2.5mg Tablet offers a non-invasive treatment option compared to intravenous chemotherapy, making it easier for patients to adhere to their treatment regimen.
5. Improvement in Fertility: For women using letrozole for fertility issues, it can help induce ovulation, increasing the chances of conception and offering hope to those struggling with infertility.

SIDE EFFECTS OF LETROZ 2.5MG TABLET 30’S

Like all medications, Letroz 2.5mg Tablet comes with potential side effects, which can vary in intensity and impact from patient to patient. Understanding these side effects is crucial for managing and mitigating their impact on patients’ lives.

1. Common Side Effects:
   • Hot Flashes: Many women experience hot flashes due to the significant reduction in estrogen levels.
   • Joint and Muscle Pain: Some patients report joint stiffness or muscle aches, which can affect mobility and quality of life.
   • Fatigue: A common side effect, fatigue can range from mild to severe, impacting daily activities and overall well-being.
   • Nausea: Some individuals may experience nausea, though it is typically mild and manageable with dietary adjustments or medication.
   • Night Sweats: Similar to hot flashes, night sweats can disrupt sleep and cause discomfort.
2. Less Common Side Effects:
   • Osteoporosis: Prolonged use of letrozole can lead to decreased bone density, increasing the risk of fractures. Regular bone density monitoring and supplements may be necessary.
   • Increased Cholesterol Levels: Some patients may experience elevated cholesterol levels, necessitating dietary changes or medication.
   • Mood Changes: Depression and mood swings can occur, requiring psychological support or medication adjustments.
3. Serious Side Effects:
   • Cardiovascular Issues: Rarely, letrozole may cause serious heart-related issues, such as chest pain or shortness of breath, requiring immediate medical attention.
   • Liver Function Changes: Abnormal liver function tests can occur, so regular monitoring is essential to detect any potential liver issues early.

REFERENCES

1. K.D. Tripathi, Essentials of medical pharmacology, Primary and secondary prevention of breast cancer. Chapter – Hormones and related drugs. Seventh Edition. 2013. Page – 314.

2. Dong-xu He Xin Ma, Clinical utility of letrozole in the treatment of breast cancer: a Chinese perspective. Onco Targets and Therapies. March 2016. [Accessed on November 08th, 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780194/pdf/ott-9-1077.pdf

3. Ajay S. Bhatnagar. The discovery and mechanism of action of letrozole. NIH: National Library of Medicine, National Center for Biotechnology Information. PMC, PubMed Central. 3 Oct 2007. [Accessed on November 08th, 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001216/

4. Accord Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised in Jan 2020] [Accessed on November 08th, 2023] https://www.medicines.org.uk/emc/files/pil.6054.pdf

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