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Product Introduction
Versavo 100mg Injection is a significant medical formulation used primarily in the treatment of various types of cancer. This product is a biosimilar of bevacizumab, which is a recombinant humanized monoclonal antibody. It functions by inhibiting vascular endothelial growth factor (VEGF), a key substance that stimulates the formation of new blood vessels (angiogenesis) in cancerous tissues. By blocking VEGF, Versavo 100mg Injection hampers tumor growth by depriving it of the necessary nutrients and oxygen supplied through the blood vessels.
Uses of Versavo 100mg Injection
Versavo 100mg Injection is utilized in the management of several types of cancers, including but not limited to:
- Colorectal Cancer: It is used in the treatment of metastatic colorectal cancer, typically in combination with other chemotherapy regimens.
- Non-Small Cell Lung Cancer (NSCLC): Versavo is effective in treating advanced stages of NSCLC, again in combination with other chemotherapeutic agents.
- Glioblastoma: This injection is also used in the case of relapsed glioblastoma, a type of brain cancer.
- Renal Cell Carcinoma: It serves as a treatment option for advanced renal cell carcinoma.
- Ovarian Cancer: Versavo is applied in the treatment of persistent, recurrent, or metastatic cervical cancer.
Benefits of Versavo 100mg Injection
The primary benefit of using Versavo 100mg Injection is its efficacy in inhibiting the growth and spread of cancer cells. Key benefits include:
- Tumor Growth Reduction: By inhibiting VEGF, Versavo effectively reduces tumor growth, which is vital in prolonging survival rates in patients.
- Enhanced Effectiveness of Chemotherapy: When used in combination with chemotherapy, Versavo enhances the effectiveness of treatment by improving the delivery of chemotherapeutic agents to the tumor and minimizing tumor resistance mechanisms.
- Delay in Disease Progression: Versavo has been shown to help delay the progression of certain types of cancers, which can be crucial for improving the quality of life in affected patients.
- Versatility: Its use across different types of cancers makes it a versatile option in oncology.
Side Effects of Versavo 100mg Injection
While Versavo 100mg Injection offers substantial benefits, it is also associated with some side effects, which can range from mild to severe. Patients must be closely monitored for these adverse effects during therapy. Common side effects include:
- Hypertension: High blood pressure is frequently observed in patients receiving Versavo due to its mechanism of action on blood vessels.
- Proteinuria: The presence of an abnormal amount of protein in the urine, which could indicate kidney issues, may occur.
- Hemorrhage: Patients may experience serious bleeding episodes, including gastrointestinal bleeding.
- Impaired Wound Healing: Due to its anti-angiogenic effects, Versavo can interfere with wound healing.
- Infusion Reactions: Like many other injectable treatments, Versavo might cause reactions at the infusion site or systemic reactions including fever, chills, or fatigue.
- Gastrointestinal Perforations: A rare but serious side effect includes the perforation of the stomach or intestines, which is a medical emergency.
References
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Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
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Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.
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Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011]. [Accessed 26 Mar. 2019] (online) Available from:
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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20]. [Accessed 18 Feb. 2020] (online) Available from:
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