Votrient 200mg Tablet

Product Introduction

Votrient 200mg Tablet, containing the active ingredient pazopanib, is a targeted therapy used in the treatment of certain types of cancer. Manufactured by GlaxoSmithKline, it falls under the category of drugs known as tyrosine kinase inhibitors (TKIs). Votrient is specifically designed to inhibit multiple tyrosine kinases, enzymes involved in the signaling pathways that regulate tumor growth and angiogenesis (the formation of new blood vessels essential for tumor growth). The inhibition of these pathways can result in the slowing or stopping of tumor growth and a reduction in the tumor’s vascular supply.

Votrient 200mg is presented in tablet form, making it suitable for oral administration, thus offering a more convenient alternative to intravenous chemotherapy for patients. Each film-coated tablet is oval-shaped and light pink, imprinted with “Pfizer” on one side and contains pazopanib hydrochloride equivalent to 200mg of pazopanib. It is generally available by prescription and is intended for daily administration under the guidance of a qualified oncologist.

Uses of Votrient 200mg Tablet

Votrient 200mg is primarily used in the treatment of advanced renal cell carcinoma (RCC), the most common type of kidney cancer in adults. It is also indicated for the treatment of advanced soft tissue sarcoma (STS) in patients who have previously received chemotherapy. RCC and STS are conditions where pazopanib has shown a significant clinical benefit.

Renal cell carcinoma patients prescribed Votrient typically have progressed to an advanced stage where surgical options are limited or ineffective. For soft tissue sarcoma, Votrient is usually considered when the disease is metastatic or cannot be removed by surgery. Its effectiveness in delaying disease progression has been validated through clinical trials, where pazopanib has consistently demonstrated the ability to significantly extend the progression-free survival rates among patients.

Benefits of Votrient 200mg Tablet

The primary benefit of Votrient 200mg lies in its targeted action against cancer cells with minimal impact on normal cells. By specifically blocking the signaling pathways important for the growth and spread of cancer cells, Votrient can effectively reduce tumor size and control its growth. Another significant benefit is the oral route of administration, which can reduce the need for hospital visits compared to traditional chemotherapy, thus improving the quality of life for patients.

Votrient has been associated with a prolongation of progression-free survival in patients with RCC and STS, which is a critical factor in cancer treatment where delaying the progression of the disease can significantly affect patient outcomes and survival rates. Furthermore, the ability to take the medication at home provides a sense of normalcy and allows patients to maintain more of their daily routines and independence.

Side Effects of Votrient 200mg Tablet

While Votrient offers significant benefits, it also comes with potential side effects, which can range from mild to severe. Common side effects include diarrhea, hypertension (high blood pressure), hair color changes, nausea, and fatigue. These are generally manageable with medical support and adjustments to the treatment regimen.

More serious side effects may include liver toxicity, which necessitates regular monitoring of liver function tests during treatment. Patients may also experience a decrease in thyroid hormone levels and should have their thyroid function monitored. An increased risk of bleeding and cardiovascular events such as heart failure has also been noted, which underscores the need for a careful assessment of the patient’s overall health and other underlying conditions before prescribing Votrient.

Due to its potential to harm a developing fetus, Votrient should not be used during pregnancy. Both men and women should use effective contraception during treatment and for a period after the last dose of Votrient to avoid pregnancy.