Semi Reclimet 40mg/500mg Tablet

Product Introduction

Semi Reclimet 40mg/500mg Tablet is a combination medication primarily used for the management of type 2 diabetes mellitus. This oral anti-diabetic medicine combines two potent active ingredients: Gliclazide (40mg) and Metformin (500mg). Gliclazide belongs to the class of sulfonylureas, which work by increasing insulin secretion from the pancreas. Metformin, on the other hand, is a biguanide that lowers glucose production in the liver, improves insulin sensitivity, and enhances glucose uptake by muscles. Together, these medications work synergistically to provide effective glycemic control, helping patients manage their blood sugar levels.

This combination therapy is often prescribed when monotherapy with either Gliclazide or Metformin fails to achieve adequate glycemic control. Semi Reclimet 40mg/500mg Tablet is formulated to be taken orally, usually once or twice a day with meals to minimize gastrointestinal side effects and enhance its absorption.

Uses of Semi Reclimet 40mg/500mg Tablet

Semi Reclimet 40mg/500mg Tablet is indicated for the treatment of type 2 diabetes mellitus, particularly in patients who do not achieve satisfactory glycemic control with diet, exercise, and monotherapy. This medication helps in:

• Controlling Blood Sugar Levels: It lowers and stabilizes blood glucose levels, reducing the risk of complications associated with uncontrolled diabetes.
• Improving Glycemic Control: By combining two different mechanisms of action, this tablet provides a more comprehensive approach to managing blood sugar levels.
• Preventing Long-Term Complications: Effective management of blood sugar levels helps prevent diabetes-related complications such as cardiovascular diseases, neuropathy, nephropathy, and retinopathy.

Benefits of Semi Reclimet 40mg/500mg Tablet

1. Enhanced Glycemic Control: The combination of Gliclazide and Metformin in Semi Reclimet 40mg/500mg Tablet offers superior glycemic control compared to either drug alone. This dual approach addresses both insulin secretion and insulin sensitivity, ensuring a more balanced blood glucose level.
2. Reduced Risk of Hypoglycemia: While sulfonylureas like Gliclazide can cause hypoglycemia, the inclusion of Metformin, which does not induce insulin secretion, helps to moderate this risk, providing a safer profile for patients.
3. Weight Management: Metformin is known to promote weight stability or modest weight loss, which is beneficial for overweight or obese patients with type 2 diabetes, contrasting the weight gain often associated with sulfonylureas.
4. Cardiovascular Benefits: Metformin has been shown to have cardiovascular benefits, including reducing the risk of myocardial infarction. This adds a layer of protection for diabetic patients who are at higher risk for cardiovascular diseases.
5. Convenience and Compliance: The combination tablet reduces the pill burden on patients, enhancing medication adherence by simplifying the treatment regimen.

Side Effects of Semi Reclimet 40mg/500mg Tablet

While Semi Reclimet 40mg/500mg Tablet is generally well-tolerated, it may cause some side effects. These can range from mild to severe, and it’s important for patients to be aware of them.

1. Gastrointestinal Disturbances: Common side effects include nausea, vomiting, diarrhea, abdominal pain, and a metallic taste. These are usually transient and can be minimized by taking the medication with food.
2. Hypoglycemia: Gliclazide can cause hypoglycemia, especially if meals are skipped or delayed, or if the patient engages in unplanned strenuous exercise. Symptoms of hypoglycemia include dizziness, sweating, palpitations, and confusion.
3. Lactic Acidosis: Although rare, Metformin can cause a serious condition called lactic acidosis, characterized by muscle pain, respiratory distress, and severe fatigue. This requires immediate medical attention.
4. Allergic Reactions: Some patients may experience allergic reactions such as rash, itching, or swelling, particularly of the face, tongue, or throat. Severe reactions, though rare, necessitate discontinuation of the drug and prompt medical intervention.
5. Vitamin B12 Deficiency: Long-term use of Metformin is associated with decreased absorption of vitamin B12, potentially leading to deficiency. Regular monitoring of vitamin B12 levels is recommended.
6. Hematologic Effects: Rarely, Gliclazide may cause hematologic side effects such as leukopenia, thrombocytopenia, or hemolytic anemia. Regular blood count monitoring is advisable for patients on long-term therapy.
7. Hepatic Dysfunction: Although infrequent, there is a potential risk of hepatic dysfunction, manifesting as jaundice or elevated liver enzymes. Liver function tests should be performed periodically.