Zomelis-D Tablet SR

Product Introduction

Zomelis-D Tablet SR combines Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin, a biguanide, to offer a dual mechanism of action against type 2 diabetes. Vildagliptin works by inhibiting the DPP-4 enzyme, which results in increased levels of incretin hormones. These hormones play a crucial role in regulating blood sugar levels by stimulating insulin release from the pancreas and reducing glucagon secretion. Metformin, on the other hand, reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

This combination is particularly beneficial for patients who require more than one drug to achieve optimal glycemic control. The sustained-release formulation allows for a steady release of the active ingredients over time, ensuring stable blood sugar levels and reducing the risk of spikes and troughs.

Uses of Zomelis-D Tablet SR

Zomelis-D Tablet SR is primarily indicated for the management of type 2 diabetes mellitus in adults. It is used as an adjunct to diet and exercise to improve glycemic control in patients who are not adequately controlled on metformin alone or who are already being treated with the combination of vildagliptin and metformin. This medication is not intended for the treatment of type 1 diabetes or diabetic ketoacidosis.

Benefits of Zomelis-D Tablet SR

1. Enhanced Glycemic Control: The combination of Vildagliptin and Metformin provides a comprehensive approach to managing blood sugar levels, addressing multiple pathophysiological defects in type 2 diabetes.
2. Reduced Risk of Hypoglycemia: Vildagliptin’s mechanism of action is glucose-dependent, meaning it primarily works when blood sugar levels are high, reducing the risk of hypoglycemia compared to other anti-diabetic medications.
3. Weight Neutrality: Unlike some other anti-diabetic drugs that can cause weight gain, Zomelis-D Tablet SR is generally weight neutral, making it a preferable option for overweight or obese patients.
4. Improved Patient Compliance: The sustained-release formulation means patients need to take the medication less frequently, improving adherence to the treatment regimen.
5. Cardiovascular Benefits: Some studies suggest that Metformin may provide cardiovascular benefits, which is crucial since cardiovascular disease is a common comorbidity in patients with type 2 diabetes.

Side Effects of Zomelis-D Tablet SR

While Zomelis-D Tablet SR is generally well-tolerated, like all medications, it can cause side effects. It is important for patients to be aware of potential adverse effects and to consult their healthcare provider if they experience any unusual symptoms.

1. Gastrointestinal Issues: Common side effects associated with Metformin include gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These symptoms are usually transient and can be minimized by taking the medication with food.
2. Lactic Acidosis: Although rare, Metformin can cause a serious condition called lactic acidosis, particularly in patients with renal impairment or other conditions that predispose them to lactic acid accumulation. Symptoms include muscle pain, respiratory distress, abdominal discomfort, and lethargy. Immediate medical attention is required if these symptoms occur.
3. Pancreatitis: Vildagliptin has been associated with cases of acute pancreatitis. Patients should be informed about the characteristic symptoms of acute pancreatitis, including severe and persistent abdominal pain, which may radiate to the back, and should discontinue the medication if these symptoms occur.
4. Hepatic Dysfunction: Vildagliptin can cause liver enzyme abnormalities. Regular monitoring of liver function tests is recommended during treatment.
5. Hypoglycemia: Although less common with Zomelis-D Tablet SR compared to other anti-diabetic medications, there is still a risk of hypoglycemia, especially if combined with other glucose-lowering agents.
6. Allergic Reactions: Some patients may experience allergic reactions, including rash, itching, and swelling. Severe reactions such as anaphylaxis are rare but require immediate medical attention.
7. Vitamin B12 Deficiency: Long-term use of Metformin has been associated with decreased absorption of vitamin B12, potentially leading to deficiency. Regular monitoring of vitamin B12 levels may be advisable.